Molecule-electron-proton transfer in enzyme-photo-coupled catalytic system

Enzyme-Photo-coupled Catalytic System (EPCS) integrates the light absorption capacity of photocatalysts and high activity/specificity enzymes, which is becoming an emerging technology platform to mimic natural photosynthesis for harnessing solar energy generate valuable products, including bulk chemicals, chemicals pharmaceutical chemicals. Cofactors NAD(P)+/NAD(P)H, as “energy currency”, are involved in over 80% biocatalytic redox reactions, establishing a bridge mass/energy exchange between photocatalysis cofactor–dependent enzyme catalysis. Although numerous efforts have been devoted, performance current EPCS far from theoretical upper limit. The individual synergistic intensification molecule-electron-proton transfer evolves critical yet challenging issue EPCS. This Review will focus on Future endeavors intensify all three transfers construct more efficient suggested pursuit new pattern modern chemical engineering.